Human anatomy few microorganisms can penetrate the intact skin

The main type of cells which make up the epidermis are Merkel cells , keratinocytes , with melanocytes and Langerhans cells also present. They are cationic peptides that are thought to kill bacteria by damaging the bacterial cell membrane. Patients with chronic granulomatous disease have a genetic deficiency of NADPH oxidase, which means that their phagocytes do not produce toxic oxygen derivatives and are less able to kill ingested microorganisms and clear the infection. Cortisol causes degradation of collagen , [20] accelerating skin aging. They are all darkly pigmented dematiaceous and exhibit a pleomorphism consisting of two distinct morphologies: The white blood cells attack the invading microorganisms and release substances that continue the process of inflammation. However, since an inflammatory response is usually initiated within minutes of infection or wounding, we will outline here how it occurs and how it contributes to host defense.
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CDC - Skin Exposures and Effects - NIOSH Workplace Safety and Health Topic

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Human skin

Figure 2. But because of their ready response to so many internal and external factors, and because changes in them often occur without a known reason, signs of abnormality can be misleading or difficult to interpret. The epidermis is composed of the outermost layers of the skin. Studies confirm that UVR damaged skin significantly increases the permeability. Toxicological Sciences.
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2-1. Infectious agents must overcome innate host defenses to establish a focus of infection

Estimates place the number of individual bacteria on the surface of one square inch 6. Human Biology and Health. Such sensitivity of response should make nails relatively good indexes of the health of individuals. The toxins can be fatal to most vertebrates or have no effect against others. Botulism is caused by ingestion of a proteinaceous exotoxin; therefore, it can easily be prevented by a.
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COM is for educational use only. The cells enter a period of dormancy, during which spontaneous respiration is maintained at a decreased level. Dermatophyte Infections The dermatophytes are fungi that colonize skin, hair, and nails on the living host. The Circulatory System IBlood. Microbial surfaces in relation to pathogenicity. These pathogens differ greatly in their lifestyles, the structures of their surfaces, and means of pathogenesis, which therefore requires an equally diverse set of defensive responses from the host immune system. To accomplish this, bacteria have evolved attachment mechanisms, such as pili fimbriae , that recognize and attach the bacteria to cells see Ch.
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